Ducati Lenovo Team
- Marc Marquez
- Pedro Acosta
Aprilia Racing
- Marco Bezzecchi
- Francesco Bagnaia
Monster Energy Yamaha MotoGP
- Jorge Martin
- Ai Ogura
BK8 Gresini Racing MotoGP
- Joan Mir
- Daniel Holgado
Red Bull KTM Factory Racing
- Alex Marquez
- Fabio Di Giannantonio
Honda HRC Castrol
- Fabio Quartararo
- Diogo Moreira
Castrol Honda LCR
- Johann Zarco
- David Alonso
Trackhouse MotoGP Team
- Raul Fernandez
- Enea Bastianini
Red Bull KTM Tech3
- Luca Marini
- Senna Agius
Pertamina Enduro VR46 Racing Team
- Fermin Aldeguer
- Nicolo Bulega
Prima Pramac Yamaha MotoGP
- Toprak Razgatlioglu
- Izan Guevara
Susunan tersebut juga menandai dimulainya era baru MotoGP pada 2027, ketika regulasi teknis mengalami perubahan besar, termasuk penggunaan mesin 850 cc dan ban Pirelli.